Fragment from Block XLVI found in 2007 in the area of the Sanctuary of Asklepios inside a Byzantine cistern. It retains parts of the torso of two men draped in himatia. The remaining part of the block is kept in the British Museum and in the Acropolis Museum its plaster cast is exhibited.

On Block XLVI three young men wrapped in their himatia lead two sacrificial heifers to the Great Altar outside of the Temple of Athena Polias. The animals move calmly following their drivers who control them with halters once rendered in colour. The heifers’ bodies could not fit the block limits and thus continue on the adjacent Blocks XLV and XLVII kept today in the British Museum.

The frieze on the south side of the Parthenon depicts part of the procession formed by the people of Athens during the Panathenaic festival in honour of the protectress of the city, Athena. The procession's destination was the Temple of Athena Polias on the Acropolis. Its purpose was the transportation of the Panathenaic peplos destined to adorn the age-old xoanon of the goddess and the offer of a grand sacrifice of animals at the Great Altar outside of the temple.

On the south frieze the procession moves along the Panathenaic Way. Youths that lead sacrificial young cows precede. They are followed by more young men who carry offerings. Behind them come musicians with guitars, officials holding olive branches, eleven chariots that participate in an equestrian event, and finally sixty riders divided in ten groups.

The south frieze is fragmentarily preserved due to the bombardment of the Parthenon by the Venetians under the command of general Francesco Morosini in 1687 which caused extensive damages to the middle of the long sides of the temple. The drawings attributed to the painter Jacques Carrey, who visited the Acropolis in 1674, just thirteen years before its bombardment by Morosini, are an invaluable resource for our understanding of quite a few parts of this side of the frieze (Blocks XX - XXXVIII). Three blocks (XXII, XXX και XXXVIII) were already lost by then as they were removed during the conversion of the Parthenon into a Christian church so that windows would be opened in the blocks' positions.

The initial length of the south frieze was 58.70 m and consisted of 47 blocks. Today the blocks are divided between the Acropolis Museum and the British Museum in London, where they ended up after they were removed by Thomas Bruce, the lord of Elgin, in 1801-1804 when Greece was still under Ottoman occupation. In order to facilitate their transportation, Elgin's workmen, cut off with saws or crowbars only the faces of the blocks that bore the relief decoration. The Acropolis Museum exhibition includes the plaster casts of these blocks' faces on which some of the original fragments that fell off the monument, and thus escaped the looting, have been adjusted.